Job: 2022BR-14

About Ambrx:

Ambrx, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics. Ambrx is based on a fundamental advance in protein biosynthesis that enables the company to genetically engineer proteins with new amino acid building blocks beyond the common twenty, enabling the biosynthesis of proteins with new physical, chemical and pharmacological properties. At Ambrx, we are dedicated to assembling and developing an exceptional team and a breakthrough technology to create the next generation of protein-based medicines.

KEY RESPONSIBILITIES

  • Support antibody-drug conjugate and immuno-oncology (IO) drug candidate characterization through independent planning and execution of pharmacology studies, including: syngeneic models, cell line derived xenografts (CDX), PBMC humanized CDX, and others
  • Design and execute in-life portions of rodent pharmacokinetic (PK) studies
  • Collaborate with project leaders to plan pharmacology needs and budgets
  • Manage a team of Research Scientists and Associates as appropriate
  • Develop novel pharmacology models as necessary
  • Analyze, interpret, and present experimental results at project team meetings
  • Provide subject matter expertise related to drug candidate exposure-activity relationships and mechanisms of action to help guide project team decisions
  • Initiate and manage in vivo studies with external CROs and/or collaborators as necessary
  • Desirable: may contribute to design and execution of in vitrofunctional assays
  • Maintain detailed records in laboratory notebooks in accordance with company policy
  • Write and review technical reports, SOPs, and scientific manuscripts for publication

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

  • PhD degree in biological science
  • For Sr. Scientist: 5+ years of industry in vivo pharmacology experience
  • Comprehensive proficiency at mouse handling, tumor cell culture and implantation, drug candidate dosing (i.v. and s.c. required), blood sample collection, and necropsy.
  • Demonstrated ability to design, perform, and interpret pharmacology and PK studies
  • Experience culturing primary human PBMCs and establishing humanized tumor models
  • Desirable: skilled in standard in vitro techniques including flow cytometry/ELISA/MSD/etc.
  • Demonstrated ability to organize and communicate complex data sets concisely
  • Excellent organizational, time-management, and multi-tasking skills
  • Consistently uses analytical thinking, persistence, and creativity to overcome challenges
  • Demonstrated ability to progress projects within a complex, matrixed, organization
  • Excellent verbal and written communication and interpersonal skills

How to Apply

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to careers@ambrx.com. Applicants whose qualifications and experience most closely match the position requirements will be contacted for further evaluation. Ambrx offers competitive compensation & benefits.  EOE

Job: 2022FR-01

Ambrx, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics. Ambrx is based on a fundamental advance in protein biosynthesis that enables the company to genetically engineer proteins with new amino acid building blocks beyond the common twenty, enabling the biosynthesis of proteins with new physical, chemical, and pharmacological properties. At Ambrx, we are dedicated to assembling and developing an exceptional team and a breakthrough technology to create the next generation of protein-based medicines.

Major Responsibilities:

Ambrx is seeking a Lab Coordinator who will be responsible for executing a wide variety of research lab duties (lab safety, inventory management, cold space storage, and managing equipment repair and maintenance).  Manages Environmental Health & Safety (EH&S) program responsibilities including waste management, training, and emergency procedures.

Research Lab:

  • Manages inventory of equipment and supplies utilized in the laboratory
  • Oversees house gas systems (N2, LN2, CO2, O2) procurement, inventory and safe storage
  • Performs preventative and corrective maintenance for refrigerators, freezers, and laboratory equipment
  • Oversees Glasswash/Autoclaving operations
    • Washing, autoclaving, restocking and labeling scientific plastic and glassware
    • Maintain common stock and office supply areas including restocking shelves
    • Assist with facility work orders

EH&S:

  • Works with external consultant regarding EH&S program and disposal of all HazMat waste in compliance with all mandated federal, state and local policies and protocols
  • Coordinates with vendors to provide annual EH&S safety, CPR and fire extinguisher training
  • Coordinates with EH&S to ensure all county (Department of Environmental Health) and fire (CEDMAT) safety inspections are successful and company is in compliance with all mandated federal, state and local policies and protocols

Shipping & Receiving:

  • Coordinates with procurement to return damaged materials to supply vendors
  • Assists all company departments with packing of large outgoing parcels
  • Other duties as assigned

Basic Qualifications:

  • Bachelor’s degree in related field, or equivalent experience; biotech industry experience is preferred
  • Must have 2+ years of relevant work experience
  • Must have Excellent organizational skills
  • Excellent communication skills, both written and verbal are required.
  • Must be able to effectively communicate and interact with all levels of staff demonstrating excellent interpersonal skills, with a team approach
  • Must be a self-starter with the ability to work independently with minimal supervision
  • Must be able to prioritize and work under tight timelines with excellent organizational skills
  • Must have excellent attention to detail and follow-up skills
  • Must have a proven track record of overseeing facilities operations
  • Must have a “hands-on” tactical approach and be familiar with laboratory glass wash and autoclave equipment and procedures
  • Must have experience managing inventory with a hands-on approach.
  • Must have advanced working knowledge of Microsoft Office with intermediate to advanced computer skills using Outlook, Word, Excel and PowerPoint
  • Must be able to perform all the essential functions of the position
  • Must be able to lift 25 lbs., stock boxes on 10’ shelves, familiarity in using dollies, pallet jacks, and manual forklifts

We offer a dynamic work environment with a competitive compensation and benefits package. Interested and qualified candidates are encouraged to send their resume to:  careers@ambrx.com.

About Ambrx:

Ambrx Inc. is a clinical-stage biopharmaceutical company focused on developing Precision Biologics using an expanded genetic code. Ambrx technology uses an expanded genetic code to incorporate synthetic amino acids into protein, all completed within a living cell. These synthetic amino acids enable the creation of Precision Biologics, an exciting new class of therapeutics with broad application and potential. This includes next-generation antibody drug conjugates (ADCs), bispecifics, and targeted immuno-oncology therapies for cancer as well as smart cytokines to modulate the immune system, and long-acting therapeutic peptides for metabolic and cardiovascular disease.

Job Description:

We are seeking a talented and motivated individual for the position of Senior Clinical Pharmacologist in Clinical Pharmacology & Pharmacometrics (CPP). In this role, you will function as a clinical pharmacology lead on project teams to drive the clinical pharmacology and model-informed drug development strategy for oncology and immune-oncology programs across all clinical development stages. In addition, you will apply clinical pharmacology knowledge to inform design of clinical pharmacology studies or clinical pharmacology component of clinical studies, conduct pharmacokinetics (PK) / pharmacodynamics (PD) analyses, and draft analysis reports.

 
Responsibilities:

  • Representing CPP and providing subject matter expertise on cross-functional project teams
  • Leading clinical pharmacology programs supporting clinical development for ADCs in oncology
  • Developing CPP plan and content for interactions with health authorities
  • Authoring/reviewing clinical protocols, analysis plans, study reports, and regulatory submissions (e.g., INDs, IBs, BLAs etc.)
  • Performing pharmacometric analyses and drafting reports for population PK and exposure-response analyses
  • Managing third-party vendors to ensure timely delivery of high-quality study reports

 

Qualifications

  • PhD or equivalent degree in Clinical Pharmacology, PK, Pharmaceutical Sciences, Biomedical Engineering, or a related scientific discipline with 2+ years’ experience or a MS degree with 4+ years of relevant experience
  • In-depth knowledge of PK, PD, and/or translational sciences.
  • Hands-on experience with PK/PD analysis using software programs (e.g., WinNonlin, NONMEM, R etc.)
  • Good oral and written communication skills and ability to convey analysis findings clearly
  • Ability to assess, prioritize and manage a diverse, time-sensitive workload

 

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to careers@ambrx.com. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.

Ambrx (NYSE: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

Ambrx is seeking a professional Administrative Assistant that will support the Chief Medical Officer with core administrative responsibilities. This position will be the initial point-of-contact with many key internal and external stakeholders on behalf of the Chief Medical Officer. This position is located in the Bay Area. Key responsibilities include:

Core administrative support

  • Extensive calendar management – proactively manages scheduling conflicts
  • Expense report management
  • Conference registration and management

Facilitating internal and external communications, meetings and events

  • Setting up external meetings with partners and suppliers
  • Setting up meetings and ensuring regular communications with key business stakeholders within Ambrx.
  • Assisting with managing events such as external speakers or other cross-functional educational or “Town Hall”- type meetings
  • Coordination of candidate interviews, sending calendar invites, securing an interview space/room, greeting candidate and booking candidate’s travel

Office and project management

  • Plans, organizes, and schedules own workload through system maintenance so that all activities are completed accurately and on time

Minimum Requirements

  • H.S. diploma required; college degree preferred.
  • 5+ years of administrative support experience.
  • Advanced proficiency in Microsoft Word, Excel, PowerPoint, and Outlook.
  • Must have strong writing and communication skills, and the ability to interact confidently with executives and employees at all levels.
  • Competency with virtual technologies (e.g., MS teams, Zoom)
  • Excellent team working, networking and influencing skills
  • Should be able to work autonomously, and at the same time, collaborate and partner effectively with other members of the administrative support community.
  • Ability to think beyond boundaries of own job, challenges the status quo and seeks opportunities for continuous improvement
  • Able to prioritize time sensitive assignments
  • Flexible to adapt to ever changing needs and deadlines.
  • Must be able to effectively multitask in a fast-paced environment while maintaining confidentiality and discretion.
  • Must be able to demonstrate tact, persuasion and/or negotiation to accomplish the objectives.
  • Previous experience in a pharmaceutical or biotechnology firm is desired.

To be considered for this opportunity, please submit your resume/CV referencing the position code to careers@ambrx.com. Applicants whose qualifications and experiences most closely match the requirements will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensations & benefits. EOE.

Job Code: 2022BR-07

Ambrx (NYSE: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

Ambrx is seeking a highly motivated and dedicated SEC Manager to be a key member of the Finance team in a fast-paced and dynamic environment. The SEC Reporting Manager will be responsible for the administration and preparation of quarterly and annual financial statements, technical accounting matters and implementation of new accounting standards, equity administration and accounting related areas (such as equity, marketable securities). The SEC Manager reports initially to the Chief Financial Officer.

Primary Responsibilities:

  • Preparation of SEC filings including 20-F, 6-Ks for FPI requirements or 8-K, 10-Q, 10-K, and 14A, etc. for domestic filer requirements, as applicable. Manage Form 3 and 4 filings, as applicable. Prepare and maintain XBRL tagging and review as part of SEC filings.
  • Prepare footnote support schedules, tie-out binders for SEC filings and disclosure checklists.
  • Support earning release process.
  • Prepare quarterly cash flow statement.
  • Administer and account for the Company’s equity incentive plans, including options, RSUs, ESPP.
  • Manage and account for the Company’s marketable securities/investment portfolio.
  • Identify complex transactions and emerging accounting standards (SEC, US GAAP, PCAOB, etc.) and research / prepare related technical accounting memos.
  • Stay abreast of SEC and FASB guidance and pronouncements.
  • Maintain quarterly/bi-annual SEC reporting schedule and coordinate internal (accounting team) and external (auditor) deliverables related to SEC filings and technical accounting memos.
  • Collaborate with the legal team to ensure compliance with SEC regulations.
  • Prepare key monthly reconciliations, including equity roll-forward and stock-based compensation and marketable securities for assigned accounting areas.
  • Examine contracts to summarize key terms and determine appropriate accounting treatment.
  • Develop, document, and maintain internal controls related to SEC filings and process and adhere to internal control procedures.
  • Ensure compliance with Company accounting and internal control policies as well as GAAP.
  • Identify and participate in process improvements, financial system enhancements and special projects as needed.
  • Completes ad-hoc financial reporting and analysis, as well as, special projects as needed, other duties as assigned.

Job Qualifications:

  • BA/BS degree in accounting or finance.
  • CPA required. Active license.
  • 6+ years of increasing finance and accounting responsibility, with a mix of public accounting and public company or pre-IPO company experience. Current SEC reporting experience is required.
  • Excellent knowledge of US GAAP, Sarbanes-Oxley (SOX), COSO, the Securities Act of 1933, the Securities Exchange Act of 1934, and XBRL
  • Experience preparing and reviewing SEC-compliant financial statements. Experience with FPI filing requirements is a plus but not required.
  • Previous experience in Biotech industry & public company experience, Big 4 or large regional experience preferred.
  • Previous experience with equity administration and equity/stock based compensation accounting required. Experience with Certent equity administration system preferred.
  • Previous experience with accounting for marketable securities required. Experience with Clearwater software solution preferred.
  • Experience using Microsoft Dynamics GP (Great Plains) preferred.
  • Experience with Workiva or other SEC reporting solution preferred.
  • Excellent interpersonal and communication skills, with the ability to approach others in a tactful manner; focus on resolving issues; maintain confidentiality, effectively influence others to effect changes, and present ideas/recommendations clearly and concisely.
  • Ability to work independently, coordinating priorities to meet deadlines. Must have ability to set own pace and prioritize multiple projects and deadlines and adapt to changing work priorities.
  • Excellent analytical skills, attention to detail, and organization.
  • Excellent written, verbal and interpersonal communication skills.

To be considered for this opportunity, please submit your resume/CV referencing the position code to careers@ambrx.com. Applicants whose qualifications and experiences most closely match the requirements will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensations & benefits. EOE.

Job: 2022BN-02

Ambrx Inc., is a clinical-stage biopharmaceutical company focused on developing Precision Biologics using an expanded genetic code. The company is focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas. Ambrx is currently seeking a Contract Coordinator.

Responsibilities:

  • Coordinate, maintain and track a high volume of contracts
  • Maintain electronic and hard copy filing systems of contracts
  • Review contractual documents to ensure adherence to company policy, compliance with language guidelines and other requirements
  • Liaise with external parties and cross-functional teams, and provide guidance regarding lifecycle of contracts
  • Perform project administration duties and assist the legal department as needed

Qualifications:

  • Bachelor’s Degree, in general business or legal disciplines preferred
  • Minimum 2 years contract coordination experience
  • Experience in corporate legal department, law firm or clinical operations group
  • Experience with a CMS highly preferred
  • Strong organizational skills
  • Excellent interpersonal and communication skills, including flexibility, tact, and diplomacy
  • Ability to work independently, accurately, and efficiently
  • Ability to maintain confidentiality of highly sensitive information
  • Detail oriented, ethical, multi-tasker, problem solving, deadline driven
  • Proficiency with MS Word, Adobe Acrobat, Excel, PowerPoint, SharePoint, and DocuSign

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to careers@ambrx.com. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.

Job: 63-21BA

Ambrx is a biopharmaceutical company enabling a new field of protein medicinal chemistry, using a fundamentally new technology that directs incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biologics products.  Ambrx is seeking a highly motivated Senior Scientist to be a key member of a fast-paced and dynamic organization.

The successful candidate will be a valuable member in the Analytical and Formulation Development group at Ambrx. As a vital member of this function, this individual should be able to maintain high standards of technical and quality excellence and may be involved in managing Associate Scientist and Research Associates on a daily basis.

 Responsibilities:

  • Develop analytical methods/assays ensuring that the projects are progressing as planned, process and products meet quality and regulatory requirements.
  • Work hands-on to develop and routinely test state-of-art analytical methods (HPLC assays, CE, icIEF, LC/MS, peptide mapping impurity characterization, glycan analysis, biophysical assays etc.); perform formulation development, compatibility, forced-degradation, and stability studies.
  • Develop and apply new technologies for characterization of complex protein molecules (including E. coli and CHO derived proteins/antibodies) and conjugates for research, process development, and clinical development.
  • Oversee and mentor junior scientists and associates, and perform assay development, qualification/validation and method transfer to CDMOs/CROs to support clinical manufacturing, release and stability studies as well as analytical comparability studies.
  • Write and diligently review analytical test methods, development reports, qualification protocols and reports, etc. Oversee method performance, release and stability studies for Reference Standard, mAb, DS, DP at CDMOs.
  • Provide expertise across functions in research, research transitioning to development and product development stages.
  • Lead efforts in protein and protein conjugates testing and characterization. Significant experience with recombinant proteins, monoclonal antibodies, ADC, bi-specifics, and PEGylated proteins highly preferred.
  • Participate in project teams to provide analytical support and coordinate resources for new and ongoing projects, from research to clinical stages.

Requirements:

  • Ph.D. in Analytical Chemistry/Pharmaceutical Sciences or related field with 6-8 yrs. of relevant industrial experience in analytical method development, formulation development and characterization for proteins.
  • Essential hands-on experience and in-depth knowledge in instrumentation and modern analytical chemistry techniques of proteins (SE-HPLC, CEX-HPLC, RP-HPLC, HIC-HPLC etc; peptide mapping, LC/MS, CE-SDS, biophysical assays such as DSC, DLS, HIAC etc.).
  • Proven record in developing and applying new technologies for complex protein molecules, attention to detail in experimental design and data quality as well as excellent troubleshooting skills.
  • Experience with assay development, qualification/validation and tech transfer to CDMOs to support clinical manufacturing. Prior experience in GMP-compliance and Quality/Regulatory Assurance.
  • Excellent oral, presentation, and written communication skills, be able to communicate effectively with reports, management, corporate functions and CDMOs.

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest to careers@ambrx.com. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.  EOE

Job: 2022FR-03

Ambrx is a biopharmaceutical company enabling a new field of protein medicinal chemistry, using a fundamentally new technology that directs incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biologics products.

 We are seeking an experienced senior level Scientist to be a key member of a dynamic and fast-paced organization. The successful candidate will provide hands-on leadership to develop stage appropriate downstream processes for clinical manufacturing of protein therapeutics. This individual will play an active role in process technology transfer, GMP manufacturing, and process characterization and validation activities at contract development and manufacturing organizations (CDMOs). Additionally, this individual will support regulatory submissions by authoring/reviewing relevant CMC sections for IND/IMPD and BLA. The successful candidate must be a goal-oriented team player with excellent troubleshooting and communication skills and adaptive to a timeline driven work environment.

Job Requirements:

  • Ph.D in Biochemistry, Biochemical Engineering, or related field with 12+ yrs industry experience in developing protein/antibody purification processes to support programs from IND-enabling to commercialization. Experience with antibody drug conjugates is highly preferred.
  • Experience in the following areas is required:
    • Leading a team for downstream process development and protein production
    • Working/managing CDMOs for technology transfer, process development, and GMP manufacturing, including document reviews (protocols, reports, manufacturing batch records)
    • Performing or overseeing process characterization and process validation to enable BLA/commercialization
    • Authoring relevant CMC sections for IND, IMPD, and BLA submissions and drafting responses to regulatory authority queries
  • Technical expertise (both hands-on experience and in-depth knowledge) in the following subjects is required:
    • Modern purification techniques for proteins and protein conjugates (chromatography, filtration (TFF and NFF), and conjugation)
    • Programming and operating chromatography and TFF systems
    • Column packing and evaluation at various scales
    • Basic analytical techniques (i.e., gel electrophoresis, HPLC, UV-Vis, ELISA, etc.)
    • Applying statistical tools (DOE and data analysis) for process development and characterization
  • Must be self-motivated, detail-oriented, collaborative, and able to work effectively in a fast-paced environment with minimal supervision.
  • Excellent communication, organization, and collaborative skills are essential.

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to careers@ambrx.com. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.  EOE

Job: 2022FR-02

Ambrx is a biopharmaceutical company enabling a new field of protein medicinal chemistry, using a fundamentally new technology that directs incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biologics products.

We are seeking an independent, experienced, and self-motivated Scientist to be a key member of the downstream process development group in a fast-paced, dynamic organization. The successful candidate will independently design, execute, and document laboratory studies supporting the research, development, and scale-up of therapeutic proteins from mammalian and microbial expression systems. The individual will develop phase‑appropriate purification processes for pre-clinical and clinical production and play an active role in technology transfer to support toxicology and clinical manufacturing at contract development and manufacturing organizations (CDMOs). Additionally, this individual must be a goal-oriented team player with excellent troubleshooting and communication skills and adaptive to a timeline driven work environment.

Job Requirements:

  • PhD/MS/BS in Biochemistry, Chemistry, Chemical Engineering, or related field with 2/6/10 years of industry experience in developing protein/antibody purification processes to support pre-clinical and clinical stage programs.
  • Experience in the downstream process development and scale-up of therapeutic proteins is required. Experience in antibody-drug conjugates (ADC) is highly preferred.
  • Hands-on experience and scientific knowledge of the following are required
    • Modern purification techniques for proteins and protein conjugates (chromatography, filtration (TFF and NFF), and conjugation)
    • Chromatography – affinity, IEX, HIC, and multi-modal
    • Programming and operating chromatography (ÄKTA) and TFF systems
    • Column packing and evaluation at various scales
    • Basic analytical techniques (i.e., gel electrophoresis, HPLC, UV-Vis, ELISA, etc.)
    • GMP manufacturing
  • Experience in process characterization, scale-up, and technology transfer to CDMO to support clinical manufacturing is highly desired.
  • Process development and optimization using statistical tools (DOE and data analysis) is a plus.
  • Proficient scientific writing skills, including protocols, reports, batch records, and regulatory filings (e.g., IND, IMPD, etc.).
  • Must be self-motivated, detail-oriented, collaborative, and able to work effectively in a fast-paced environment with minimal supervision.
  • Excellent communication, organization, and collaborative skills are essential.

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to careers@ambrx.com. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.  EOE

Job: 11-22BA

Ambrx (NYSE: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

Ambrx is seeking a highly motivated and dedicated Assistant Controller to be a key member of the Finance team in a fast-paced and dynamic environment. The position oversees the payroll and cash accounts management functions and will directly support the SEC and external reporting functions. The Assistant Controller will ensure accurate and timely processing and recording of the company’s financial transactions and ensures compliance with internal controls. The Assistant Controller reports to the VP of Accounting Operations and Financial Reporting.

Primary Responsibilities:

  • Responsible for all aspects of accounting management and executes on the day-to-day accounting operations which includes: accounts payable, account receivable and revenue recognition, general ledger, fixed assets, clinical trial accounting, tax compliance, payroll, cash & cash equivalents, marketable securities.
  • Responsible for consolidated financial statements including consolidations of subsidiaries and manages subsidiary accounting records.
  • Manage the Accounts Payable Manager and Payroll Supervisor and work with internal managers of different departments.
  • Work with the VP of Accounting Operations and Financial Reporting, responsible for timely and successful completion of external financial audits and quarterly reviews.
  • Develop and manage clinical trial and manufacturing accounting accruals.
  • Ensure appropriate recognition, classification and safeguarding of fixed assets and intangible assets.
  • Develop documentation of standards and procedures for the accounting and finance teams’ processes.
  • Proactively researches and resolves accounting or documentation issues and discrepancies.
  • Responsible for timely and accurate month end close and monthly account reconciliations (consolidation workbook, supplemental schedules, rollforwards, reconciliations, etc.). Produce monthly reporting package and financial statements.
  • Create and post journal entries to the general ledger, including month-end recurring and accrual entries. Consolidation and elimination entries.
  • Monitoring actual versus budget, including variance analysis; perform analytics to explain variances for the balance sheet actual results as compared to prior periods.
  • Maintain and monitor the system of internal accounting controls and ensure their efficiency and effectiveness.
  • Lead as primary contact for inquires, from internal and external representatives.
  • Ensures the effectiveness of internal controls and integrity of accounting records and resulting financial statements
  • Ensuring all accounting practices are in compliance with legal guidelines and established accounting principles
  • Ensures an ERP system (Great Plains) is configured and maintained to optimally support the company’s accounting needs.
  • Supports company’s SEC filing on quarterly / annual basis (i.e. such as footnote preparation and support)
  • Supports ongoing financial planning and analysis and financial forecasting.
  • Provide timely and accurate reporting of all federal, state, and local tax filings (income taxes, property taxes, sales and use taxes, franchise taxes, 1099s etc.);
  • Completes ad-hoc financial reporting and analysis, as well as, special projects as needed, other duties as assigned.

 

Job Qualifications:

  • BA/BS degree in accounting or finance.
  • Active CPA.
  • 10+ years relevant finance and accounting experience including previous experience at the Assistant Controller or Director level.
  • Previous experience in Biotech industry & public company experience, Big 4 or large regional experience preferred.
  • Previous experience with clinical trial, research and development, and outsourced manufacturing accounting desired.
  • Demonstrated ability in leading and building an accounting function from the ground-up, including recruitment, development and retention of top industry talent.
  • Proven ability to analyze financial data and prepare financial reports, statements, and projections
  • Strong knowledge of U.S. GAAP and Sarbanes-Oxley.
  • Ability to research and interpret accounting guidance.
  • Strong knowledge and experience using Microsoft Dynamics GP (Great Plains).
  • Excellent analytical skills, attention to detail, and organization.
  • Excellent written, verbal and interpersonal communication skills.

To be considered for this opportunity, please submit your resume/CV referencing the position code to careers@ambrx.com. Applicants whose qualifications and experiences most closely match the requirements will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensations & benefits. EOE.