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Medical Director, Clinical Development

Location: California remote (may consider remote in other US locations)

(Job 2023-BN-09)

Ambrx (NASDAQ: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

The Medical Director, Clinical Development is responsible for leading the scientific and medical strategic planning and oversight of assigned clinical development program(s). May also serve in the capacity of Program Lead to drive execution of the clinical development plan.

Responsibilities:

  • Serve as medical subject-matter expert by maintaining and leveraging up-to-date knowledge in areas of therapeutic interest to the program.
  • Oversee the design and medical/scientific execution of clinical trials from pre-IND onwards to clearly meet program objectives, oversee patient safety, and ensure protocol compliance.
  • Promote a culture of innovation to bring forward creative development plans that maximize the potential of the asset.
  • Support the Chief Clinical Officer by providing medical input into Clinical Development Plan, Integrated Development Plan, and Clinical Trial Protocol reviews.
  • Provide clinical leadership and strategic medical input for all clinical deliverables in the assigned project or section of a clinical program
  • Lead development of clinical sections of trial and program level regulatory documents
  • Act as a medical director for assigned studies including conducting ongoing reviews of medical/safety data; collaborates with others in development of case report forms, data management and statistical analysis plans; participates in investigator and other external presentations, meetings and other communications.
  • Act as a core member of the patient safety team, supporting overall program safety reporting in collaboration with Drug Safety team.
  • As a medical expert, supporting the Chief Clinical Officer in interactions with external and internal stakeholders and decision boards.
  • Drive execution of the assigned clinical program and/or clinical trial in partnership with Program Leads, functional management, and executive leadership.
  • If also serving in the role of Program Lead:
    • Collaborates with relevant teams and other groups to measure and monitor study progress against objectives and plans, including any variances, and proactively communicate any issues, challenges and potential strategies to resolve; acts as point of contact and project representative to portfolio team/ to enable decision-making, including information dissemination and the resolution of critical project issues.
    • Serves as the team’s champion by negotiating and influencing key internal stakeholders.
    • Creates a motivated, committed and engaged project team.
    • Models and expects effective team behavior to achieve the project goals.
    • Establishes cross-functional relationships with leaders from key cross-functional lines: Regulatory Affairs, Clinical Operations, Program Management, etc.
    • Leverages those relationships to manage key interdivisional interfaces on project issues including but not limited to Research, Development, Manufacturing and Competitive Intelligence
    • Leverages functional line expertise to achieve the team goals.
    • Collaborates with others to ensure consistency of processes
  • Supports clinical operations, clinical data management, biostatistics, clinical research organizations (CROs), etc. by acting as a point-of-contact for scientific/medical questions, other communications, and interactions, identifying investigators and sites.

Requirements:

  • MD or equivalent medical degree is required in addition to advanced knowledge and clinical training in medical/scientific area; Clinical practice experience 4 years (including residency) and board certification or eligibility in oncology preferred.
  • Minimum of 7 years of experience in clinical research or drug development within industry
  • Experience in an academic clinical research or industry environment spanning clinical activities in Phases I through IV required.
  • 5+ years of contribution to and accomplishment in all aspects of conducting clinical trials (e.g., planning, executing, reporting and publishing) in a in pharmaceutical industry required.
  • Working knowledge of disease area is required, with proven ability to interpret, discuss and present efficacy and safety data relating to clinical trial(s) and proven ability to understand and interpret basic and clinical scientific research reports.
  • Demonstrated ability to establish effective scientific partnerships with key stakeholders.
  • Working knowledge of GCP, clinical trial design, statistics, and regulatory and clinical development processes
  • Previous global people management experience is preferred, though this may include management in a matrix environment.

Pay Scale:

The pay scale for this position is annualized at: $285,000 to $385,000, commensurate with experience. We believe this to be the possible compensation range for this role at the time of this posting, and we may modify this pay scale in the future.

To be considered for this opportunity, please submit your resume/CV referencing the position code to careers@ambrx.com. Applicants whose qualifications and experiences most closely match the requirements will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensations & benefits. EOE.

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Director, Clinical Pharmacology

(Job 2023-BN-11)

 

Ambrx (NASDAQ: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

Ambrx is seeking a highly motivated Director, Clinical Pharmacology to lead and actively contribute to the development and execution of clinical pharmacology and pharmacometrics strategies across the Ambrx portfolio; participates in the design of clinical and relevant non-clinical studies; and interprets, presents and reports clinical and non-clinical study results.

Primary Responsibilities:
The Director, Clinical Pharmacology ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.

  • Acts as the lead clinical pharmacologist for multiple clinical stage programs.
  • Leads, and actively contributes to, the development of overarching clinical pharmacology strategies from IND to NDA (or BLA) to support regulatory submissions.
  • Leads the development of, and implements, optimal dose-finding strategies to ensure safe and effective advancement of clinical programs, including FIH dose selection, dose escalation and dose recommendation for the phase II and registration trials.
  • Leads, and actively contributes to the design and execution of clinical pharmacology studies to evaluate PK in special populations.
  • Leads, and actively contributes to, the design and execution of clinical drug-drug interaction and food effect studies following regulatory guidance.
  • Drafts Investigator’s Brochures (IBs), eCTD modules, and clinical study protocols in close partnership with clinical operations, medical, regulatory, biostatistics, and medical writing professionals.
  • Leads and performs PK analyses in non-compartmental model for the drug and/or metabolites.
  • Contribute to population PK/PD analyses and integrates this knowledge into the overall clinical development strategy(ies).
  • Evaluates and selects Contract Research Organizations (CROs) and manages/actively oversees outsourced PK and PK/PD.
  • Coaches and mentors team members.

Job Requirements:

  • PhD in a relevant scientific discipline OR a PharmD and a minimum of 5+ years of progressively responsible experience in a pharmaceutical, biotechnology or related environment
  • Demonstrated understanding or, and experience applying, clinical pharmacology concepts.
  • Familiar with regulatory guidance especially for drug interaction studies.
  • Highly proficient in performing NCA PK analysis using Phoenix WinNonlin.
  • Demonstrated expertise in developing and executing drug metabolism and pharmacokinetics studies.
  • Experience with common population PK/PD modeling software packages (such as NONMEM)
  • Preferred experience with common modeling software
  • Demonstrate understanding of formulation and toxicology.
  • Experience managing multiple projects with competing priorities.
  • Demonstrated experience in writing study reports and regulatory documents.
  • Ability to influence without direct authority.
  • Excellent verbal and written communication and skills.
  • Ability to work independently and collaboratively. as required, in a fast-paced, matrixed, team environment consisting of internal and external team members.
  • Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.
  • Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.
  • Excellent management and interpersonal skills.
  • Up to 10% travel
  • Experiences in Oncology

Pay Scale:

The pay scale for this position is annualized at: $210,000 to $250,000, commensurate with experience.  We believe this to be the possible compensation range for this role at the time of this posting, and we may modify this pay scale in the future.

To be considered for this opportunity, please submit your resume/CV referencing the position code to careers@ambrx.com. Applicants whose qualifications and experiences most closely match the requirements will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensations & benefits. EOE.

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Research Associate II, Technology

(Job 2023BR-08)

 

About Ambrx:

Ambrx (NASDAQ: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

Ambrx is seeking a highly motivated Research Associate to join the Discovery Group. The primary responsibility is to support multiple oncology and immune-oncology projects from discovery to the preclinical phase. The candidate will work in a multidisciplinary and dynamic team environment to help with discovery and develop precision engineered biological drugs that change patients’ lives.

Major Responsibilities:

  • Work in the Discovery Group to support multiple discovery projects to expand Ambrx’s early pipeline
  • Build DNA constructs for various formats of biological therapeutics
  • Collaborate seamlessly with cell culture group to quickly deliver protein material for discovery projects
  • Generate recombinant stable cell lines for assay development and preclinical animal models
  • Develop and perform in vitro biological assays to characterize drug candidates

Job Requirements:

  • MS degree with 0-4 years of experience, or BS degree with 2-4 years of experience, in the biotech and /or pharmaceutical industry
  • Prior experience or good knowledge in molecular biology, especially in cloning, PCR, and vector construction
  • Prior experience or good knowledge in recombinant protein expression in a wide variety of systems (bacterial, mammalian cells)
  • Prior experience in aseptic tissue culture, in vitro biological assays, ELISA desirable
  • Prior experience working with oncology and immune-oncology therapeutic proteins and translational science is a plus
  • Demonstrated passion to learn and advance new technology
  • Ability to work independently and collaboratively in a matrixed team environment
  • Good oral/ written communication and strong problem-solving skills

Pay Scale:

The pay scale for this position is annualized at: $ 65,000 to $ 80,000, commensurate with experience. We believe this to be possible compensation for this role at the time of this posting, and we may modify this pay scale in the future.

To be considered for this opportunity, please submit your resume/CV referencing the position code to careers@ambrx.com. Applicants whose qualifications and experiences most closely match the requirements will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensations & benefits. EOE.

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Assistant Controller/Director of Finance

(Job Code: 2023-BN-07)

 

Ambrx (NASDAQ: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

 

Ambrx is seeking a highly motivated and dedicated Assistant Controller/Director of Finance to be a key member of the Finance team in a fast-paced and dynamic environment. The position oversees the month-end close functions and will directly support the SEC and external reporting functions. The Assistant Controller/Director of Finance will ensure accurate and timely processing and recording of the company’s financial transactions and ensures compliance with internal controls. The Assistant Controller/Director of Finance reports to the VP/Controller.

 

Primary Responsibilities:

  • Responsible for all aspects of monthly close activities including: accounts payable, account receivable and revenue recognition, general ledger, fixed assets, clinical trial accounting, tax compliance, payroll, cash & cash equivalents.
  • Responsible for internal consolidated financial statements including consolidations of subsidiaries and manages subsidiary accounting records.
  • Work with the VP/Corporate Controller, responsible for timely and successful completion of external financial audits and quarterly reviews.
  • Review and provide input to the clinical trial and manufacturing accounting accruals.
  • Ensure appropriate recognition, classification and safeguarding of fixed assets and intangible assets.
  • Develop documentation of standards and procedures for the accounting and finance teams’ processes.
  • Proactively researches and resolves accounting or documentation issues and discrepancies.
  • Responsible for timely and accurate month end close and monthly account reconciliations (consolidation workbook, supplemental schedules, rollforwards, reconciliations, etc.). Produce monthly reporting package and financial statements.
  • Create and post journal entries to the general ledger, including month-end recurring and accrual entries. Consolidation and elimination entries.
  • Responds to actual versus budget inquiries, including variance analysis; perform analytics to explain variances for the balance sheet actual results as compared to prior periods.
  • Maintain and monitor the system of internal accounting controls and ensure their efficiency and effectiveness.
  • Provide support for inquiries as necessary, from internal and external representatives.
  • Ensures the effectiveness of internal controls and integrity of accounting records and resulting financial statements
  • Ensuring all accounting practices are in compliance with legal guidelines and established accounting principles
  • Able to work efficiently within ERP system (Great Plains) to support the company’s accounting needs.
  • Supports company’s SEC filing on quarterly / annual basis (i.e. such as footnote preparation and support)
  • Supports ongoing financial planning and analysis and financial forecasting.
  • Provide timely and accurate reporting of all federal, state, and local tax filings (income taxes, property taxes, sales and use taxes, franchise taxes, 1099s etc.);
  • Completes ad-hoc financial reporting and analysis, as well as, special projects as needed, other duties as assigned.

 

Job Qualifications:

  • BA/BS degree in accounting or finance.
  • Active CPA.
  • 10+ years relevant finance and accounting experience including previous experience at the Assistant Controller or Director level.
  • Previous experience in Biotech industry & public company experience, Big 4 or large regional experience preferred.
  • Previous experience with clinical trial, research and development, and outsourced manufacturing accounting desired.
  • Demonstrated ability in leading an accounting function, including recruitment, development and retention of top industry talent.
  • Proven ability to analyze financial data and prepare financial reports, statements, and projections
  • Strong knowledge of U.S. GAAP and Sarbanes-Oxley.
  • Ability to research and interpret accounting guidance.
  • Strong knowledge and experience using Microsoft Dynamics GP (Great Plains).
  • Excellent analytical skills, attention to detail, and organization.
  • Excellent written, verbal and interpersonal communication skills.
  • This is a hybrid position. Candidate may be required to visit the Torrey Pines office on a regular basis.

 

Pay Scale:

The pay scale for this position is: $190,000 to $230,000, commensurate with experience.  We believe this to be possible compensation for this role at the time of this posting, and we may modify this pay scale in the future.

 

To be considered for this opportunity, please submit your resume/CV referencing the position code to careers@ambrx.com. Applicants whose qualifications and experiences most closely match the requirements will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensations & benefits. EOE.

 

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Principal Scientist, Mammalian Cell Culture Development

(Job: 2023-BR-07)

 

About Ambrx:

Ambrx is a clinical-stage biopharmaceutical company enabling a new field of protein medicinal chemistry, using a technology that directs the incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biological products such as antibody-drug conjugates. Ambrx is seeking a highly motivated scientific leader to be a key member of a fast-paced and dynamic organization.

Job Description:

Responsibilities:

This position will focus on upstream process development and lead the efforts for developing and optimizing the cell culture process including medium development, feeding strategies, process parameter optimization, process characterization and scale-up for large scale production to support R&D, pre-clinical, and clinical activities. This individual will design and carry out experiments and provide technical leadership and serve as the subject matter expert on project teams and work closely with other groups to provide support for the Company’s projects. The candidate will monitor, explore and evaluate next generation technologies to speed up process development. This individual will also be responsible for technology transfer to third parties including partners and CMO.. The role will involve authoring of development reports and CMC sections for regulatory submissions including INDs and BLAs.

Requirements:

  • Ph.D with 12+ yrs industry experience or MS with 16+ yrs industry experience in Biochemical Engineering, Chemical Engineering, Biochemistry or related field
  • Hands-on experience with CHO and other mammalian cell for mAb or recombinant protein production is a must
  • Hands-on experience using spin tubes, shake flasks, stirred tank bioreactors, automated microbioreactor systems and ATF equipemnt is required
  • Previous experience in cell culture scale-up, tech transfer including drafting development reports, production batch records, protocols and Knowledge of scale-up and scale-down models is highly desired.
  • Knowledge of statistical design of experiments in process development and optimization
  • Previous experience in cell culture media development and cell culture platform development is plus
  • The ability to succeed in a multidisciplinary, fast changing and diverse team environment
  • Working knowledge of GMP and experience with US IND/BLA filings are highly desirable

Pay Scale:

The annualized pay scale for this exempt position is: $145,000 to $175,000, commensurate with experience.  We believe this to be possible compensation for this role at the time of this posting, and we may modify this pay scale in the future.

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to careers@ambrx.com. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.  EOE

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Associate Director, Clinical Data Management

(Job: 2023-BN-08)

 

Ambrx Biopharma, Inc. (NASDAQ: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

SUMMARY: 

Ambrx is seeking a highly dedicated Associate Director to collaborate with cross-functional teams (including medical, clinical science, biostatistics, PK, and biomarker analysts) to ensure complete and quality clinical data collection for oncology clinical trials. Oversees activities of data management CRO, organize and facilitate internal team data review, and performs hands-on data review as needed. Liaise with 3rd party vendors to facilitate routine data transfers in a consistent format. Contribute to the evaluation and implementation of clinical data collection systems, processes, and service providers.

 

KEY RESPONSIBILITIES:

  • Participate as the primary data management representative on multidisciplinary project teams and ensure effective communication exchange.
  • Provide a high level of expertise in data management of oncology clinical studies, including areas such as: electronic Case Report Form (eCRF) design, electronic data capture (EDC) database design, data management plans, edit checks/data quality review plans, query resolution processes, data transfers, SAE/AE reconciliation, thesaurus coding processes, vendor oversight plans and database lock.
  • Effectively manage data management Clinical Research Organizations (CROs) to provide routine metrics, high compliance, and high-quality deliverables within timeline and budget
  • Oversee and conduct quality review of clinical trial data
  • Manage time and resource constraints across multiple projects.
  • Ensure data management components of the Trial Master File maintained by the CRO are complete and inspection-ready at all times.
  • Develop and implement new or improved processes for data management.
  • Participate in development of Request For Proposals (RFPs) and evaluation of vendors, products and proposals.
  • Provides oversight on quality and timeliness of task completion by direct reports.
  • Develops and implement training curriculum for data management activities and principles as required.

 

SUPERVISORY RESPONSIBILITIES:

  • Directly supervises zero to 4 employees or contractors
  • Indirectly supervise employee (s) through a dotted line structure or via other subordinate supervisors.

 

EDUCATION/EXPERIENCE/SKILLS:   

Education:

  • BS/BA degree in related discipline and 8 years of related experience; or,
  • MS/MA degree in related discipline and 7 years of related experience; or,
  • Equivalent combination of education and experience.

Experience:

  • Typically requires a minimum of 10 years of related experience and/or combination of experience and education/training.
  • Experience in Biotech/Pharmaceutical industry with oncology focus preferred.

Knowledge/Skills/Abilities:

  • Experience in solid-tumor oncology clinical trials required.
  • Expertise with EDC systems, e.g. RAVE, Inform
  • Experience with eCRF design for solid-tumor oncology
  • Deep understanding of the nuances of solid-tumor oncology data to facilitate development of data review checks and ability to drive/adjudicate/prioritize data queries.
  • Demonstrated success managing data management activities of Clinical Research Organizations (CROs).
  • Ability to train and oversee cross-functional staff on key data management tasks, including eCRF/EDC design, data quality review, and standardized data transfers.
  • Knowledge of Good Clinical Practices (GCP) is essential.

Pay Scale:

The annualized pay scale for this exempt position is: $155,000 to $180,000, commensurate with experience.  We believe this to be possible compensation for this role at the time of this posting, and we may modify this pay scale in the future.

 

To be considered for this opportunity, please submit your resume/CV referencing the position code to careers@ambrx.com. Applicants whose qualifications and experiences most closely match the requirements will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensations & benefits. EOE.

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Associate Director, Drug Product Manufacturing

Location: (Position can be remote)

(Job: 2023-BN-13)

About Ambrx: 

Ambrx Biopharma, Inc. (NASDAQ: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

We are seeking an experienced and highly motivated leader in drug product manufacturing to be a key member of the CMC team in a dynamic and fast-paced organization. The successful candidate will be responsible for overseeing drug product GMP manufacturing at contract development and manufacturing organizations (CDMOs) to authoring/reviewing drug product sections for regulatory submissions. Additionally, this individual must be a goal-oriented team player with excellent troubleshooting and communication skills and adaptive to a timeline driven work environment.

Major Responsibilities:

  • Oversee drug product GMP manufacture and related activities at CDMOs, including timely review/approval of batch records and related manufacturing documents, manage tech transfer and production progress at the CDMO, help to troubleshoot any issues related to drug product manufacture and release, and serve as the person-in-plant for manufacturing activities.
  • Author and review drug product sections for regulatory submissions, including original IND/IMPD, IND/IMPD amendments, BLA, and response to queries from global regulatory authorities.
  • May manage formulation development and drug product process development (including lyophilization cycle development) at CDMOs.
  • Proactively identify potential problems or opportunities in CMC areas to facilitate advancement of product candidates.

Job Requirements:

  • PhD/MS/BS in Biochemistry, Chemical Engineering, or related field with 12+ years of experience in biopharmaceutical industry.
  • Hands-on experience working in a cleanroom environment and in drug product manufacturing of biologics.
  • Experience and knowledge in the entire drug product manufacturing process, from drug substance thawing and compounding, sterile filtration, filling, stoppering, lyophilization, capping, to visual inspection and labeling.
  • Familiar with filtration systems, filling lines, filling isolators, and environmental monitoring.
  • Experience in CDMO management and working closely with the Quality Assurance and Clinical Supply Chain Management functions.
  • Experience in risk management, deviation and root-cause investigations and CAPAs.
  • Experience in writing CMC sections of IND.
  • Experience in antibody drug conjugate (ADC) manufacturing is highly preferred.
  • Experience in formulation development, lyophilization cycle development, drug product process characterization and validation, equipment validation, and cleaning validation are highly desired.
  • Must be proactive, detail-oriented, collaborative, and able to work effectively in a fast-paced environment with minimal supervision.
  • Excellent communication, organization, and collaborative skills are essential.

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to careers@ambrx.com. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits. EOE

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Senior Director, SEC Reporting and Technical Accounting

(Job: 2023-BR-03)

 

Job Description

Ambrx Biopharma, Inc. (NASDAQ: AMAM) is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

 

Ambrx is seeking a highly motivated and dedicated  Sr. Director, SEC Reporting and Technical Accounting to be a key member of the Finance team in a fast-paced and dynamic environment. The  Sr. Director, SEC Reporting and Technical Accounting will be responsible for the administration and preparation of quarterly and annual financial statements, technical accounting matters and implementation of new accounting standards, equity administration and accounting related areas (such as equity, marketable securities). The Director, SEC Reporting and Technical Accounting reports to the Chief Financial and Operating Officer.

 

Primary Responsibilities:

  • Manage external reporting process and preparation of SEC filings including 10-Q, 10-K, 8-K, and 14A, S-3, S-8, etc. for domestic filer requirements. Manage Form 3 and 4 filings, as applicable. Prepare and maintain XBRL tagging and review as part of SEC filings.
  • Prepare footnote support schedules, tie-out binders for SEC filings and disclosure checklists.
  • Support earning release process.
  • Prepare quarterly cash flow statement.
  • Administer and account for the Company’s equity incentive plans, including options, RSUs, ESPP.
  • Manage and account for the Company’s marketable securities/investment portfolio.
  • Support equity/debt transactions, M&A and business development activities, on ad-hoc basis. Support company valuation projects.
  • Identify complex transactions and emerging accounting standards (SEC, US GAAP, PCAOB, etc.) and research / prepare related technical accounting memos.
  • Stay abreast of SEC and FASB guidance and pronouncements.
  • Maintain quarterly/bi-annual SEC reporting schedule and coordinate internal (accounting team) and external (auditor) deliverables related to SEC filings and technical accounting memos.
  • Collaborate with the legal team to ensure compliance with SEC regulations.
  • Prepare key monthly reconciliations, including equity roll-forward and stock-based compensation and marketable securities for assigned accounting areas.
  • Examine contracts to summarize key terms and determine appropriate accounting treatment.
  • Develop, document, and maintain internal controls related to SEC filings and process and adhere to internal control procedures.
  • Ensure compliance with Company accounting and internal control policies as well as GAAP.
  • Implements formal processes for obtaining and analyzing information gathered from internal business units for financial report preparation. Completes ad-hoc financial reporting and analysis, as well as, special projects as needed, other duties as assigned.
  • Support fundraising / investor relations related efforts on as needed basis

 

Job Qualifications:

  • BA/BS degree in accounting or finance.
  • CPA required.
  • Minimum of 8 – 10+ years of increasing finance and accounting responsibility, with a mix of public accounting and public company or pre-IPO company experience. Current SEC reporting experience is required.
  • Excellent technical knowledge of US GAAP and SEC reporting requirements
  • Experience preparing and reviewing SEC-compliant financial statements.
  • Previous experience in Biotech industry & public company experience, Big 4 or large regional experience preferred.
  • Previous experience with equity administration and equity/stock based compensation accounting required. Experience with Certent equity administration system preferred. Experience with American Depository Share programs (non-US entity) is a plus, but not required.
  • Previous experience with accounting for marketable securities required. Experience with Clearwater software solution preferred.
  • Experience using Microsoft Dynamics GP (Great Plains) preferred.
  • Experience with Workiva, Active Disclosure or other SEC reporting solution preferred.
  • Develops, modifies and executes company policies that affect immediate operations and may also have company-wide effect.
  • Excellent interpersonal and communication skills, with the ability to approach others in a tactful manner; focus on resolving issues; maintain confidentiality, effectively influence others to effect changes, and present ideas/recommendations clearly and concisely.
  • Excellent time management, organizational, and project management skills with experience in working toward tight deadlines
  • Comfortable working in a fast-paced environment and adept at handling change
  • Ability to effectively facilitate and present in group meetings
  • Strong analytical, problem-solving, and strategic-thinking skills with a forward-looking focus
  • Excellent analytical skills, attention to detail, and organization.
  • Excellent written, verbal and interpersonal communication skill

Pay Scale:

The annualized pay scale for this exempt position is: $200,000 to $235,000, commensurate with experience.  We believe this to be possible compensation for this role at the time of this posting, and we may modify this pay scale in the future.

To be considered for this opportunity, please submit your resume/CV referencing the position code to careers@ambrx.com. Applicants whose qualifications and experiences most closely match the requirements will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensations & benefits. EOE.

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