Job 2023BN-04

Ambrx is a biopharmaceutical company enabling a new field of protein medicinal chemistry, using a fundamentally new technology that directs incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biologics products.

Job Responsibilities:

We are seeking an independent, experienced, and self-motivated Scientist to be a key member of the downstream process development and Bioconjugation group in a fast-paced, dynamic organization. The successful candidate will:

  • Independently design, execute, and document studies supporting the research, development, and scale-up of therapeutic proteins from mammalian and microbial expression systems
  • Develop phase‑appropriate downstream processes for research and clinical production
  • Play a role in technology transfer to support toxicology and clinical manufacturing at contract development and manufacturing organizations (CDMOs)
  • Will be a goal-oriented team player with excellent troubleshooting and communication skills and adaptive to a timeline driven work environment

Job Requirements:

  • PhD with 4 years, MS with 8 years, or BS with 12 years of industry experience in Biochemistry, Chemistry, Chemical Engineering, or related field developing protein/antibody purification processes to support pre-clinical and clinical stage programs.
  • Experience in the downstream process development and scale-up of therapeutic proteins is required. Experience in antibody-drug conjugates (ADC) is highly preferred.
  • Hands-on experience and scientific knowledge of the following are required
    • Modern purification techniques for proteins and protein conjugates (chromatography, filtration (TFF and NFF), and conjugation)
    • Chromatography – affinity, IEX, HIC, and multi-modal
    • Programming and operating chromatography (ÄKTA) and TFF systems
    • Column packing and evaluation at various scales
    • Basic analytical techniques (i.e., gel electrophoresis, HPLC, UV-Vis, ELISA, etc.)
  • Experience in process characterization, scale-up, and technology transfer to CDMO to support clinical manufacturing is highly desired.
  • Process development and optimization using statistical tools (DOE and data analysis) is a plus.
  • Proficient scientific writing skills, including protocols, reports, batch records. Regulatory filings (e.g., IND, IMPD, etc.) is a plus.
  • Must be self-motivated, detail-oriented, collaborative, and able to work effectively in a fast-paced environment with minimal supervision.
  • Excellent communication, organization, and collaborative skills are essential.

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.