SAN DIEGO–(BUSINESS WIRE)–Ambrx, a clinical stage biopharmaceutical company using an expanded genetic code technology platform to discover and develop Engineered Precision Biologics (EPBs), today announced the formation of a Scientific Advisory Board (SAB) comprised of industry leaders in oncology and protein sciences, chaired by Peter Schultz, Ph.D. The SAB will work cohesively with management to advance the company’s clinical development pipeline of Engineered Precision Biologics.

“I’m delighted to be appointed Chair of Ambrx’s Scientific Advisory Board, and to be part of such a distinguished group of industry experts”

“The prestigious group of scientific thought leaders we have assembled to sit on our Scientific Advisory Board will provide Ambrx with relevant and informed counsel in the months and years ahead, as we continue our research efforts and further the development of our clinical pipeline,” said Feng Tian, Ph.D., Chairman of the Board, President and CEO of Ambrx. “Each member brings unique experience from technology, protein drug design, immunology, early-stage research to the late-stage clinical development of human therapeutics. I believe this collection of keen minds and experience will serve us well as we develop EPBs for the treatment of cancer, with a focus on our lead development candidate, ARX788.”

The founding members of the Ambrx Scientific Advisory Board are:

Peter Schultz, Ph.D., is currently President and CEO of Scripps Research and a Professor of Chemistry. He has made innovative and pioneering contributions to chemical and synthetic biology, notably the rational expansion of the genetic codes of living organisms and the exploitation of molecular diversity in the synthesis of new medicines and materials. Schultz has authored over 600 scientific publications, trained over 300 coworkers, and founded nine companies that have pioneered the application of molecular diversity technologies to address multiple challenges in human health and materials science. He has won many Awards, including the Wolf Prize, Solvay Prize and Cope Award and is a member of the National Academies of Science of and Medicine.

Stuart Lutzker, M.D., Ph.D., is an industry veteran with decades of oncology drug development and leadership experience. Most recently, Dr. Lutzker was Vice President of Oncology Early Clinical Development at Genentech from 2009-2021 where he led the early development of multiple now approved oncology drugs including Kadcyla®, Polivy®, Venclexta®, Cotellic® and Tecentriq®. Prior to Genentech, Dr. Lutzker was a medical oncologist and cancer researcher at the NCI-Designated Cancer Institute of New Jersey, where he divided his time between patient care and laboratory-based cancer research. Dr. Lutzker received his M.D./Ph.D. in Biochemistry from Columbia University College of Physicians and Surgeons. Following his residency and fellowship in Internal Medicine and Medical Oncology at Yale-New Haven Hospital, Dr. Lutzker completed post-doctoral research training in the Department of Molecular Biology at Princeton University. Dr. Lutzker has also served as faculty for the ASCO/AACR Methods in Clinical Cancer Research Workshop in Vail, CO.

Jakob Dupont, M.D., is a renowned expert in oncology, immunology and cell therapy with vast experience in developing therapies and programs, especially for breast and gynecological cancers. Dr. Dupont is the Global Head of Research & Development and EVP at Atara Biotherapeutics and is a Director at Apexigen. Prior to Atara, Dr. Dupont served as Chief Medical Officer at Gossamer Bio. Prior to Gossamer, Dr. Dupont served as Global Head of Breast and Gynecologic Cancer Development and VP for Genentech/Roche. Dr. Dupont received his M.D. from the Joan & Sanford I. Weill Medical College of Cornell University and his M.A. in philosophy from New York University.

Melissa Starovasnik, Ph.D., is an accomplished scientific leader and 28-year Genentech veteran who led their large-molecule drug discovery organization as VP, Protein Sciences from 2011-2017, while overseeing discovery and optimization of more than 20 protein therapeutic candidates. Prior to that she headed operations for the >1300-member research organization as VP, Research Operations & Structural Biology. Most recently, she served as Senior Scientific Advisor, Research, which included leading efforts to advance diversity and inclusion within the organization. Dr. Starovasnik received her Ph.D. from the University of Washington in biochemistry, completed a postdoctoral fellowship at Genentech in protein NMR spectroscopy, and has co-authored more than 70 scientific publications and patent applications.

Luisa Salter-Cid, Ph.D., M.Sc., is the Chief Scientific Officer at Pioneering Medicines, a division of life sciences company Flagship Pioneering. Before this, she served at Chief Scientific Officer at Gossamer Bio where she established a large research team and clinical portfolio that was integral in the company’s IPO in 2019. Prior to Gossamer Bio, Dr. Salter-Cid served as Vice President at Bristol-Myers Squibb, heading the immunology, small molecule immuno-oncology and genomics teams. Presently, Dr. Salter-Cid serves on the Board of Directors for Jounce Therapeutics and is a member of the Scientific Advisory Boards of both Prometheus Biosciences and Enterome. She has authored over 80 publications and patents, and received her doctorate in immunology from the University of Miami.

Feng Tian, Ph.D., is the Chairman of the Board, President and CEO of Ambrx, and has been with the company about 17 years. Formerly Ambrx’s Chief Scientific Officer, Dr. Tian has overseen the company’s research and development. He led team to establish various technology programs such as the EuCODE platform and antibody drug conjugate platform. Prior to Ambrx, Dr. Tian conducted his post-doctoral study at The Scripps Research Institute under Peter Schultz. Dr. Tian received his Ph.D. in chemistry from the University of Florida and his B.S. in chemistry from Peking University.

About Ambrx

Ambrx is a clinical stage biopharmaceutical company using an expanded genetic code technology platform to discover and develop Engineered Precision Biologics. These include next generation antibody drug conjugates (ADCs), bispecifics, targeted immuno-oncology therapies, novel cytokines to modulate the immune system, and long-acting therapeutic peptides for metabolic and cardiovascular disease. Ambrx is advancing a robust portfolio of clinical and preclinical programs designed to optimize efficacy, safety and ease of use, in multiple therapeutic areas, including its lead product candidate ARX788. In addition, the company has clinical collaborations with Bristol Myers Squibb, Astellas, BeiGene, Sino Biopharma, Elanco and NovoCodex, for drug candidates generated using Ambrx technology.

Source: Ambrx

Contacts
INVESTORS
Laurence Watts
Managing Director
Gilmartin Group, LLC.
619-916-7620
laurence@gilmartinir.com

MEDIA
Ian Stone
Managing Director
Canale Communications
(619) 849-5388
ian@canalecomm.com

SAN DIEGO, Calif., April 14, 2021 – Ambrx, a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics, today announced the appointments of Olivia C. Ware and Katrin Rupalla, Ph.D., to its Board of Directors.

“We are thrilled to have both Olivia and Katrin join the Ambrx team at a such a pivotal time in the company’s history,” said Feng Tian, Ph.D., Chairman of the Board, President and CEO of Ambrx. “Olivia brings invaluable experience across all stages of the product development cycle, from pharmaceutical drug development and commercialization to healthcare management. Katrin has extensive experience in global regulatory strategy and drug candidate development. I look forward to benefiting from Olivia and Katrin’s counsel in the months and years to come, as we advance our clinical development pipeline, including our lead asset ARX788.”

“I am delighted to be appointed to Ambrx’s Board and joining what I believe to be a very talented and highly capable team,” said Ms. Ware. “I hope to leverage my clinical and commercial experience as we collectively seek to advance an innovative pipeline of drugs from Ambrx’s technology platform.”

Ms. Ware joins Ambrx with more than 20 years of pharmaceutical drug development, commercialization and healthcare management experience, with a history of successful commercial drug launches including Rituxan®, Herceptin®, Avastin® and Lucentis®. In addition to drug development, Ms. Ware also has experience in developing managed care, pricing and contract strategy, developing marketing programs for field-based sales teams, and establishing, growing and optimizing organizations for long-term success. Previously, Ms. Ware was the Senior Vice President, BTK Franchise Head at Principia Biopharma Inc., where she was responsible for developing portfolio strategy for the company’s three BTKi molecules. Prior to that, she served as Senior Vice President, U.S. Market and Franchise Development at Proteus Digital Health, Inc., was Chief Commercial Officer at CytRx, Inc., and held various leadership roles at Genentech, Inc.

Ms. Ware graduated from Davidson College and received her MBA from the University of North Carolina at Chapel Hill. She is now President of Davidson College Board of Visitors and member of the Davidson Board of Trustees.

“I’m excited to be joining Ambrx, especially given the recent clinical progress the company has made in both China and the United States,” said Dr. Rupalla. “I look forward to assisting the company’s regulatory affairs and drug development efforts in both countries, so that we can together progress Ambrx’s innovative Engineered Precision Biologics to create more precise therapeutic treatments to address significant unmet needs.”

Dr. Rupalla has more than 25 years’ experience in the pharmaceutical industry at a global scale serving the United States, Europe and China. Currently, Dr. Rupalla serves as Senior Vice President of Regulatory Affairs, R&D Quality and Medical Information at Lundbeck. Prior to joining Lundbeck, she spent several years at Bristol Myers Squibb in various roles in drug development and regulatory affairs including as Head Development BMS in China, Vice President of European Union Regulatory Sciences, and Vice President of Oncology Global Regulatory Sciences. Dr. Rupalla has spent her career as an executive in global regulatory affairs at various other companies including Celgene, Roche, and Merck. Presently, she is a non-executive independent director at 4D Pharma PLC and iQure Pharma Inc.

Dr. Rupalla received a Master of Science in Pharmacy and a Ph.D. in CNS pharmacology from Philipps University of Marburg, Germany. She also has an MBA from Jones International University, CO, USA.

About Ambrx

Ambrx is a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics. These include next generation antibody drug conjugates (ADCs), bispecifics, targeted immuno-oncology therapies, novel cytokines to modulate the immune system, and long-acting therapeutic peptides for metabolic and cardiovascular disease. Ambrx is advancing a robust portfolio of clinical and preclinical programs optimized for efficacy, safety and ease of use, in multiple therapeutic areas, including its lead product candidate ARX788. In addition, the company has clinical collaborations with Bristol Myers Squibb, Astellas, BeiGene, Sino Biopharma, Elanco and NovoCodex, for drug candidates generated using Ambrx technology. For additional information, please visit www.ambrx.com.

 

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Contacts

INVESTORS
Laurence Watts
Managing Director
Gilmartin Group, LLC.
619-916-7620
laurence@gilmartinir.com

SAN DIEGO, Calif., March 17, 2021 – Ambrx, a clinical stage biopharmaceutical company using an expanded genetic code to create Engineered Precision Biologics, today announced that the U.S. Food and Drug Administration (FDA) has granted the company orphan drug designation for ARX788 for the treatment of patients with HER2-positive gastric cancer, including cancer at the gastroesophageal junction.

The FDA’s Office of Orphan Drug Products grants orphan status to support the development of medicines for underserved patient populations, or rare disorders, that affect fewer than 200,000 people in the U.S. Orphan drug designation for ARX788 for gastric cancer provides Ambrx with certain benefits, including an exemption to FDA prescription drug user fees and tax credits for qualified clinical trials. Orphan drug designation also confers eligibility for seven years of market exclusivity to an orphan drug post-approval, subject to receiving marketing approval from the FDA.

“The ongoing Phase 1 ACE-Gastric-01 trial has shown promising anti-tumor activity in HER2-positive advanced gastric patients who have been previously treated with trastuzumab and chemotherapy in the metastatic setting,” said Feng Tian, Ph.D., President and CEO of Ambrx. “Receiving orphan drug designation from the FDA is an important milestone in our ongoing efforts to develop ARX788 for a wide range of HER2-positive cancers. We are proud to be targeting a rare disease that is currently severely underserved by advancing ARX788 into additional clinical trials.”

The company anticipates the release of additional Phase 1 data from the ACE-Gastric-01 trial by the end of 2021 and initiation of ACE-Gastric-02, a global Phase 3 trial for HER2-positive gastric cancer, in the second half of 2021. ACE-Gastric-02 is currently planned to be a randomized trial of ARX788 versus physician’s choice of treatment in second line HER2-positive gastric cancer and HER2-positive cancer at the gastroesophageal junction.

About ARX788
ARX788 is a homogeneous and highly stable antibody drug conjugate (ADC) targeting the HER2 receptor. ARX788 is an Engineered Precision Biologic ADC that consists of two cytotoxic payloads site-specifically conjugated to a Herceptin® (trastuzumab)-based antibody. ARX788 was designed to maximize potential anti-tumor activity by optimizing the number and position of the payloads and the chemical bonds that conjugate the cytotoxic AS269 payloads to the antibody. AS269 is a proprietary tubulin inhibitor specifically designed to form a highly stable covalent bond with our synthetic amino acids, a fundamental step in the creation of an Engineered Precision Biologic ADC. Ambrx licensed the China rights to ARX788 to its partner NovoCodex.

About HER2-positive Gastric Cancer
Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase receptor growth-promoting protein found on the surface of some cancer cells. Gastric cancer with HER2 overexpression has shown aggressive biological behavior, with higher frequencies of disease recurrence in HER2-positive tumors. The frequency of HER2 overexpression in gastric cancer, and cancer at the gastroesophageal junction, range widely with an average of 20% expression. The heterogeneity within gastric tumors and poor treatment options shows an unmet medical need for patients with HER2-positive advanced gastric cancer.

About Ambrx
Ambrx is a clinical stage biopharmaceutical company using an expanded genetic code platform to create Engineered Precision Biologics. These include next generation antibody drug conjugates (ADCs), bispecifics, targeted immuno-oncology therapies, novel cytokines to modulate the immune system, and long-acting therapeutic peptides for metabolic and cardiovascular disease. Ambrx is advancing a robust portfolio of clinical and preclinical programs optimized for efficacy, safety and ease of use, in multiple therapeutic areas, including its lead product candidate ARX788. In addition, the company has collaborations with Bristol Myers Squibb, Astellas, BeiGene, Sino Biopharma, Elanco and NovoCodex, for drug candidates generated using Ambrx technology. For additional information, please visit www.ambrx.com.

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Contacts

INVESTORS
Laurence Watts
Managing Director
Gilmartin Group, LLC.
619-916-7620
laurence@gilmartinir.com

MEDIA
Ian Stone
Managing Director
Canale Communications
(619) 849-5388

SAN DIEGO, Calif., February 23, 2021 – Ambrx, a clinical stage biopharmaceutical company using an expanded genetic code to create Engineered Precision Biologics, today announced the appointment of Chris Nolet to the company’s Board of Directors. Mr. Nolet brings extensive experience as a long-time audit partner and business advisor in the life sciences industry, and has assumed the role of Chair of Ambrx’s Audit Committee.

“We are delighted that Chris will be joining our Board of Directors given his deep expertise, knowledge base and industry network,” said Feng Tian, Ph.D., President and CEO of Ambrx. “His experience in helping transition clinical stage companies into commercially integrated pharmaceutical companies should prove invaluable to Ambrx. As Chair of the Audit Committee, he will provide the accounting and financial oversight to support Ambrx through the next stages of the company’s growth. I am confident that Chris will prove to be an indispensable board member and look forward to benefiting from his counsel in the years ahead.”

“I am very pleased to join Ambrx’s Board at such a pivotal time in the company’s history, and to help the development of Ambrx’ Engineered Precision Biologics, which could dramatically improve the treatment outcomes for a variety of cancer patients,” said Mr. Nolet. “Ambrx recently completed a $200 million private financing round that included some of the world’s leading healthcare investors. In addition, Ambrx’s lead development candidate, ARX788, has generated promising clinical data, and received Fast Track Designation from the FDA as a potential monotherapy for the treatment of metastatic HER2-positive breast cancer patients.”

Mr. Nolet currently serves on the Boards of Viela Bio (NASDAQ: VIE), where he is Chair of the Audit Committee, PolarityTE, Inc. (Nasdaq: PTE), where he is Chair of the Audit Committee, and Revance Therapeutics (NASDAQ: RVNC), where he is also Chair of the Audit Committee. In addition, Mr. Nolet serves on both the Executive Committee and Finance Committee (Co-Chair) of the California Life Sciences Association (CLSA), and is a former member of the Finance & Investment Committee and Emerging Companies Section of the Biotechnology Innovation Organization.

Mr. Nolet is the former West Region Life Sciences Industry Leader & Partner at EY, retiring in June of 2019 after more than 38 years in the profession. In addition to serving clients, his responsibilities included leading West Region EY Life Sciences Industry Group, and serving as a member of the Global EY Life Sciences Executive Leadership Group, which established policies and operating strategies for EY Life Sciences practice worldwide. Prior to joining EY, Mr. Nolet was a partner at PricewaterhouseCoopers where he led the life sciences practice in the western U.S. He holds a B.S. in accounting from San Diego State University and is a Certified Public Accountant in California (retired).

About Ambrx

Ambrx is a clinical stage biopharmaceutical company using an expanded genetic code to create Engineered Precision Biologics. These include next generation antibody drug conjugates (ADCs), bispecifics, targeted immuno-oncology therapies, novel cytokines to modulate the immune system, and long-acting therapeutic peptides for metabolic and cardiovascular disease. Ambrx is advancing a robust portfolio of clinical and preclinical programs optimized for efficacy, safety and ease of use, in multiple therapeutic areas, including its lead product candidate ARX788. In addition, the company has clinical collaborations with Bristol Myers Squibb, Astellas, BeiGene, Sino Biopharma, Elanco and NovoCodex, for drug candidates generated using Ambrx technology. For additional information, please visit www.ambrx.com.

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Contacts

INVESTORS
Laurence Watts
Managing Director
Gilmartin Group, LLC.
619-916-7620
laurence@gilmartinir.com

MEDIA
Ian Stone
Managing Director
Canale Communications
(619) 849-5388
ian@canalecomm.com

SAN DIEGO, Jan. 4, 2021 /PRNewswire/ — Ambrx announced that the U.S. Food and Drug Administration (FDA) granted ARX788 Fast Track Designation as monotherapy for the treatment of advanced or metastatic HER2-positive breast cancer patients who have received one or more prior anti-HER2 based regimens in the metastatic setting.

“This is an important milestone for ARX788 that underscores the strong unmet medical need to develop new and effective treatment options for breast cancer patients whose tumors progressed on currently approved HER2 directed regimens,” said Joy Yan, MD, PhD, Ambrx Chief Medical Officer. “It’s our mission to drive science forward to help bring innovative therapeutic options to cancer patients and we look forward to working closely with the FDA to optimize and expedite the development of ARX788.” This designation was granted based on the phase 1 studies that assessed the safety, tolerability, pharmacokinetic (PK), and preliminary efficacy of ARX788.

About ARX788

ARX788 is a homogeneous and highly stable antibody drug conjugate (ADC) targeting the HER2 receptor. ARX788 is a Precision Biologic ADC that consists of two cytotoxic payloads site-specifically conjugated to a Herceptin® (trastuzumab) based antibody. ARX788 was designed for maximum performance in the preclinical setting by optimizing the number, position and chemical bonds that conjugate the cytotoxic AS269 payload to the antibody. AS269 is a proprietary tubulin inhibitor specifically designed to form a highly stable covalent bond with our synthetic amino acids, a fundamental step in the creation of a Precision ADC. Ambrx licensed the China rights of ARX788 to its partner NovoCodex.

About HER2-positive Metastatic Breast Cancer

Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase receptor growth-promoting protein found on the surface of some cancer cells. About 20% of breast cancers overexpress the HER2/neu gene, which causes these cancers to grow more aggressively. Unmet medical needs remain today in HER2-positive metastatic breast cancer. Many tumors progressed after currently approved HER2-targeted regimens.

About Ambrx

Ambrx Inc. is a clinical stage biopharmaceutical company using an expanded genetic code to create Precision Biologics, this includes next generation antibody drug conjugates (ADCs), bispecifics, and targeted immuno-oncology therapies for cancer as well as novel cytokines to modulate the immune system and long-acting therapeutic peptides for metabolic and cardiovascular disease, all designed to have improved pharmacologic properties and novel biological activity. Leveraging the Ambrx proprietary technology platforms, Ambrx has collaborations with Bristol Myers Squibb, Astellas, BeiGene, Sino Biopharma, Elanco and NovoCodex, with drug products generated using Ambrx technology in different stages of clinical trials. Ambrx is advancing a robust portfolio of clinical and preclinical programs optimized for efficacy, safety and ease of use in multiple therapeutic areas. For additional information, visit www.ambrx.com.

About Fast Track Designation

Fast Track Designation is designed by the FDA to facilitate the development and expedite the review of drugs to treat serious conditions that have the potential to address unmet medical needs. The designation enables early and frequent communication with the FDA and is intended to accelerate drug approval and patient access to novel treatment options.

Contact:
Amy Conrad
858-366-3243
amy@juniper-point.com

SOURCE Ambrx Inc.

• 74% ORR in the Phase 1 HER2-positive Breast Cancer Trial in China and 67% ORR in the Phase 1 HER2 Expressing Pan-tumor Trial in US/AU
• Multiple Global Phase 2/3 Trials to Begin Early 2021

SAN DIEGO, December 10, 2020 – Ambrx Inc., a clinical-stage biopharmaceutical company focused on developing Precision Biologics using an expanded genetic code, provided a clinical update on their lead program ARX788, a homogeneous and highly stable, site-specific antibody drug conjugate (ADC) targeting HER2 positive cancers.

“As presented at the 2020 San Antonio Breast Cancer Symposium, ARX788 Phase 1 studies demonstrated promising antitumor activity in heavily pre-treated cancer patients at the recommended Phase 2 dose,” said Joy Yan, MD, PhD, Ambrx Chief Medical Officer.

• ORR of 74% (14/19) and DCR of 100% in the 1.5 mg/kg cohort of the Phase 1 HER2-positive breast cancer trial in China
• ORR of 67% (2/3) and DCR of 100% in the 1.5 mg/kg cohort of Phase 1 HER2-positive pan tumor trial in U.S. and Australia
• mDOR or mPFS at the 1.5 mg/kg dose have not been reached.
• ARX788 was well-tolerated, with most adverse events being mild or moderate, and were manageable.

Patients who failed prior Kadcyla® (T-DM1) or Enhertu® (DS-8201a) achieved clinical responses, as assessed by RECIST v1.1 in the ACE-Pan Tumor-01 (ARX788-1711) trial, which enrolled patients with HER2 expressing cancers including breast cancer, gastric/gastroesophageal junction adenocarcinoma, non-small cell lung cancer, bladder, colorectal, biliary track, and salivary gland cancers in US and Australia.

“The randomized controlled Phase 2/3 HER2-positive breast cancer pivotal trial in China has treated 22 subjects as of December 5th, 2020 and continues to quickly enroll patients,” said Dr. Xichun Hu, the leading PI of the ongoing ARX788 Phase 1 and Phase 2/3 trials in China.
“We remain on track to open multiple global ARX788 registrational studies next year, with the first study in HER2-positive breast cancer patients who failed prior T-DM1, T-DXd, or tucatinib-containing regimens starting in early 2021. These global registrational studies are designed to obtain BLA and sBLA in HER2 positive breast cancer, HER2 positive gastric cancer, HER2-low breast cancer, and other HER2-expressing or HER2-mutated solid tumors,” said Dr. Yan.

About ARX788
ARX788 is a homogeneous and highly stable antibody drug conjugate (ADC) targeting the HER2 receptor. ARX788 is a Precision Biologic ADC that consists of two cytotoxic payloads site-specifically conjugated to a Herceptin® (trastuzumab) based antibody. ARX788 was designed for maximum performance in the preclinical setting by optimizing the number, position and chemical bonds that conjugate the cytotoxic AS269 payload to the antibody. AS269 is a proprietary tubulin inhibitor specifically designed to form a highly stable covalent bond with our synthetic amino acids, a fundamental step in the creation of a Precision ADC. Ambrx is developing and commercializing ARX788 with its partner NovoCodex.

About NovoCodex
NovoCodex Biopharmaceuticals, Inc., a majority owned subsidiary of Zhejiang Medicine Co. Ltd. (ZMC), is focused on developing novel next-generation cancer therapeutics for the China market, including ARX788 and ARX305. ZMC, a major China-based pharmaceutical company listed on the Shanghai stock exchange, is a leading global manufacturer of fat-soluble vitamins and bacteria-resistant antibiotics. ZMC’s products are exported to the United States and many EU countries.

About Ambrx
Ambrx Inc. is a clinical stage biopharmaceutical company using an expanded genetic code to create Precision Biologics, this includes next generation antibody drug conjugates (ADCs), bispecifics, and targeted immuno-oncology therapies for cancer as well as novel cytokines to modulate the immune system and long-acting therapeutic peptides for metabolic and cardiovascular disease, all designed to have improved pharmacologic properties and novel biological activity. Leveraging the Ambrx proprietary technology platforms, Ambrx has collaborations with Bristol Myers Squibb, Astellas, BeiGene, Sino Biopharma, Elanco and NovoCodex, with drug products generated using Ambrx technology in different stages of clinical trials. Ambrx is advancing a robust portfolio of clinical and preclinical programs optimized for efficacy, safety and ease of use in multiple therapeutic areas. For additional information, visit www.ambrx.com.

SAN DIEGO, November 9, 2020 – Ambrx Inc., a clinical-stage biopharmaceutical company focused on developing Precision Biologics using an expanded genetic code announced today the successful closing of an oversubscribed US$200 million crossover financing round.

New investors include Fidelity Management & Research Company LLC, funds and accounts managed by BlackRock, Cormorant Asset Management, HBM Healthcare Investments, Invus, Adage Capital Partners and Suvretta Capital Management. BofA Securities acted as the sole placement agent for the offering.

“This financing represents our most significant capital raise to date and includes several leading global and US based healthcare funds. Since mid-2018, our new management team, set on a new long term vision, has committed to building company fundamentals and transforming Ambrx from a technology developer to a full-fledged biopharmaceutical company,” said Dr. Feng Tian, CEO and Chairman of Ambrx. “The conclusion of this financing and the strong data emerging from our ongoing clinical programs, as well as our deep preclinical pipeline of proprietary drug candidates, positions the company for rapid growth.”

Ambrx technology uses an expanded genetic code to incorporate synthetic amino acids into protein, all completed within a living cell. These synthetic amino acids enable the creation of Precision Biologics, an exciting new class of therapeutics with broad application and potential. This includes next generation antibody drug conjugates (ADCs), bispecifics, and targeted immuno-oncology therapies for cancer as well as smart cytokines to modulate the immune system, and long acting therapeutic peptides for metabolic and cardiovascular disease.

The company’s innovation engine continues to expand the clinical and preclinical pipeline by discovering new and valuable programs that take full advantage of the Ambrx technologies. These novel programs have the potential to address a wide range of diseases with new or improved mechanisms of action, providing the company with a rich set of programs to develop internally or in partnership with leading pharmaceutical companies.

About Ambrx

Ambrx Inc. is a clinical stage biopharmaceutical company using an expanded genetic code to create Precision Biologics, this includes next generation antibody drug conjugates (ADCs), bispecifics, and targeted immuno-oncology therapies for cancer as well as novel cytokines to modulate the immune system and long acting therapeutic peptides for metabolic and cardiovascular disease, all designed to have improved pharmacologic properties and novel biological activity. Leveraging the Ambrx proprietary technology platforms, Ambrx has collaborations with Bristol-Myers Squibb, Astellas, BeiGene, Sino Biopharma, Elanco and ZMC, with drug products generated using Ambrx technology in different stages of clinical trials. Ambrx is advancing a robust portfolio of clinical and preclinical programs optimized for efficacy, safety and ease of use in multiple therapeutic areas. For additional information, visit www.ambrx.com.