Job: 75-21BA

About Ambrx:

Ambrx is a biopharmaceutical company enabling a new field of protein medicinal chemistry, using a fundamentally new technology that directs incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biologics products.  Ambrx is seeking a highly motivated scientist to be a key member of a fast-paced and dynamic organization.

Job Description:

  • Lead the cell line development (CLD) group to optimize CLD process to further improve efficiency and shorten timeline.
  • Improve transient expression titer of mAb or other therapeutic proteins to quickly provide gram of material for discovery projects.
  • Collaborate seamlessly with cell culture group to deliver production cell lines for GMP manufacturing and to develop platform batch/fed batch cell culture process.
  • Represent CLD function to participate internal and external project meetings, provide scientific insights and contribute to regulatory filings.
  • Mentor and manage junior scientists and maintain instruments in cell culture laboratories.

Requirements:

  • PhD molecular biologist or biochemist with 6+ years’ of Quality Control experience or MS with 8+ years’ of Quality Control experience in the biotech and/or pharmaceutical industry. PhD molecular biologist or biochemist with 6+ years’ of Quality Control experience or MS with 8+ years’ of Quality Control experience in the biotech and/or pharmaceutical industryCell biologist or molecular biologist with the degree of PhD with 5 years or MS with 8 years or BS with 10+ years of experience in the biotech and/or pharmaceutical industry.
  • Expertise in recombinant protein expression in a wide variety of systems (bacterial, mammalian cell lines) in industry setting.
  • Proven track record in industry-relevant mammalian expression system (CHO, HEK293 et al) using transient, stable bulk pool format as well as GMP stable cell line development and cell line engineering.
  • Knowledge and hands-on experience in general molecular biology, especially in cloning, PCR and vector construction.
  • Excellent hands-on skills in aseptic tissue culture, ELISA, HPLC, Octet.
  • Working experience in cell culture ranging from microplates, deep-well plates to shake flask. Knowledge and hands on experience in wave bag is a plus.
  • Skills in operation and maintenance of imager, cell counter, multitron, wave bag.
  • Skilled in writing cell line related technical report for tech transfer and regulatory filing.
  • Demonstrated passion to learn and advance new technology.
  • The ability to succeed in a multidisciplinary and dynamic team environment.
  • Independent thinking and team player. Experience in training and leading junior scientists is a plus.
  • Good communication and strong problem-solving skills

 

 

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest to careers@ambrx.com. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.  EOE