Job: 2022FR-02

Ambrx is a biopharmaceutical company enabling a new field of protein medicinal chemistry, using a fundamentally new technology that directs incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biologics products.

We are seeking an independent, experienced, and self-motivated Scientist to be a key member of the downstream process development group in a fast-paced, dynamic organization. The successful candidate will independently design, execute, and document laboratory studies supporting the research, development, and scale-up of therapeutic proteins from mammalian and microbial expression systems. The individual will develop phase‑appropriate purification processes for pre-clinical and clinical production and play an active role in technology transfer to support toxicology and clinical manufacturing at contract development and manufacturing organizations (CDMOs). Additionally, this individual must be a goal-oriented team player with excellent troubleshooting and communication skills and adaptive to a timeline driven work environment.

Job Requirements:

  • PhD/MS/BS in Biochemistry, Chemistry, Chemical Engineering, or related field with 2/6/10 years of industry experience in developing protein/antibody purification processes to support pre-clinical and clinical stage programs.
  • Experience in the downstream process development and scale-up of therapeutic proteins is required. Experience in antibody-drug conjugates (ADC) is highly preferred.
  • Hands-on experience and scientific knowledge of the following are required
    • Modern purification techniques for proteins and protein conjugates (chromatography, filtration (TFF and NFF), and conjugation)
    • Chromatography – affinity, IEX, HIC, and multi-modal
    • Programming and operating chromatography (ÄKTA) and TFF systems
    • Column packing and evaluation at various scales
    • Basic analytical techniques (i.e., gel electrophoresis, HPLC, UV-Vis, ELISA, etc.)
    • GMP manufacturing
  • Experience in process characterization, scale-up, and technology transfer to CDMO to support clinical manufacturing is highly desired.
  • Process development and optimization using statistical tools (DOE and data analysis) is a plus.
  • Proficient scientific writing skills, including protocols, reports, batch records, and regulatory filings (e.g., IND, IMPD, etc.).
  • Must be self-motivated, detail-oriented, collaborative, and able to work effectively in a fast-paced environment with minimal supervision.
  • Excellent communication, organization, and collaborative skills are essential.

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to careers@ambrx.com. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.  EOE