Job: 76-21BA

Ambrx is a clinical-stage biopharmaceutical company enabling next generation protein therapeutics using an expanded genetic code to produce high value biologics such as long-acting proteins, antibody drug conjugates (ADCs) and bi-specific antibodies. At Ambrx, we are dedicated to assembling and developing an exceptional team and a breakthrough technology to create next generation protein therapeutics.

Ambrx is seeking a highly creative and motivated organic/medicinal chemist with project leadership skills to be part of a growing chemistry team, who can contribute to discovering novel protein therapeutics to help patients in need.

Primary Responsibilities:

  • The successful candidate will lead internal/external programs and cross-functional teams to execute project plans
  • Lead our ADC, payload, linker, peptide design strategies and synthesis
  • Independently carryout structure-activity relationship studies and interpret experimental results to propose new compound designs
  • Proven ability to initiate new programs and understanding of biology concepts to deliver proof-of-concept data to make Go/No Go decisions
  • Proven ability to identify problems and propose solutions to move programs forward
  • Carryout analytical and preparative method development to support internal chemistry needs
  • Communicate research findings to the key stake holders and present in project meetings/conferences
  • Contribute to patent application writing and research reports
  • Identify and establish working relationships with CROs and manage external chemistry resources
  • Safe keeping and operation of lab and lab equipment


  • PhD. in organic/medicinal chemistry or related field with minimum 8-12 years of industry experience
  • Experience working with antibody drug conjugates and understanding of ADC field is a requirement
  • Proven track record in ADC project leadership and demonstrated success in payload identification/optimization, and carrying out SAR studies
  • Experience in structure-based and pharmacophore-based drug designs
  • Experience in modern synthetic organic chemistry techniques, designing new synthetic routes for biologically active molecules and carrying out multi-step synthesis in milligram to multi-gram scale
  • Hands-on experience with analytical and purification equipment including HPLC, LC-MS and NMR
  • Experience working with small molecule CDMOs and contributing to CMC section writings is a plus
  • Excellent presentation skills, communication, organization, and collaborative skills are essential


To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.